Senior Principal AI Research Engineer

Summary by AIEngineer.careers

Senior Principal AI Research Engineer is a AI Research Engineer role (full-time). with 140 Pfizer Inc. in BOTHELL, US. Compensation shown: $139K–$232K. Imported listing (source: pfizer.wd1.myworkdayjobs.com). Apply on the employer's site (pfizer.wd1.myworkdayjobs.com).

Imported listing (source: pfizer.wd1.myworkdayjobs.com) · Apply on pfizer.wd1.myworkdayjobs.com

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BOTHELL · US

$139K–$232K

Full-time

SENIOR

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Imported job description

Sourced from pfizer.wd1.myworkdayjobs.com

Pfizer is building an AI-native operating model for drug discovery and seeks a Senior Principal AI Research Engineer to design and deliver production-grade AI systems. You will own end-to-end subsystems spanning multimodal biomedical models, agentic AI, RAG, and inference services that enable scientists across R&D. The role combines strong software engineering fundamentals with applied machine learning and cross-functional collaboration with AI scientists and computational biologists.

Responsibilities

Design, develop, and deploy production-grade AI systems supporting multimodal biomedical models and intelligent agents
Engineer data pipelines, retrieval systems, evaluation frameworks, knowledge systems, and inference services
Lead architecture, implementation, testing, deployment, monitoring, and continuous improvement for owned areas
Translate scientific and business needs into technical solutions and drive projects from concept to production
Contribute to architecture reviews, code reviews, and engineering standards; mentor less-experienced engineers
Define success metrics and continuously improve performance, reliability, and scientific impact

Requirements

PhD with 2+ years, Master's with 5+ years, or Bachelor's with 6+ years of relevant experience
Demonstrated experience designing and delivering production software or machine learning systems
Strong Python development skills and proficiency with PyTorch or JAX
Experience with software architecture, APIs, testing, debugging, version control, and CI/CD
Experience building reliable systems in cloud, distributed computing, or HPC environments
Depth in one or more areas: distributed GPU training, model serving, MLOps, LLM/agentic architectures, RAG, or AI evaluation
Proven ability to work across interdisciplinary teams and communicate technical concepts broadly

Nice to Have

Experience in life sciences, healthcare, biotechnology, or regulated industries
Experience with multimodal AI, scientific machine learning, computational biology, or cheminformatics
Experience implementing responsible AI practices, evaluation frameworks, and governance controls
Evidence of technical impact via deployed systems, publications, patents, or open-source contributions

Benefits

401kHealth insurancedental insurancevision insurancepaid vacationpaid holidaysParental leaverelocation assistancebonusEquity / stock options

Tech Stack

Agentic AIAI EvaluationCI/CDDistributed TrainingDockerInference OptimizationJAXKnowledge GraphsKubernetesLLMsMLOpsMultimodal LearningPythonPyTorchRAG

140 Pfizer Inc

New York · US · 75000+ employees

Pfizer Inc. is a research-based, global biopharmaceutical company that applies science and global resources to bring therapies to people that extend and significantly improve their lives. Founded in 1849, Pfizer works across developed and emerging markets to advance wellness, prevention, treatments, and cures that challenge the most feared diseases of our time. The company is one of the world's premier innovative biopharmaceutical companies with a global portfolio of medicines and vaccines.